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How the Human Immune System Works

A plain-language overview of innate and adaptive immunity, and why vaccines train the immune system.

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Medically reviewed by

Dr. Priya Raman, MD

Internal Medicine, Medical Editor

Review dates

Published 2026-04-15
Last review 2026-05-20
Next review 2026-11-20

Jurisdictions

Global

Two layers of defence

The innate immune system responds quickly and generically — skin, mucus, and cells that attack anything foreign. The adaptive system learns: it builds antibodies and memory cells targeted to specific pathogens.

Immune memory

After an infection or vaccination, memory cells persist. If the same pathogen returns, the response is faster and stronger, which is the biological basis of immunity and of vaccination.

Limits of this overview

Immune function varies with age, medication and medical conditions. Questions about your own immunity belong with a clinician.

Sources & Citations

  1. [1]Understanding How Vaccines Work — U.S. CDC

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